The role of cytokines in the regulation of NK cells in the tumor environment.

  title={The role of cytokines in the regulation of NK cells in the tumor environment.},
  author={Gordana M Konjevi{\'c} and Ana Vuleti{\'c} and Katarina M Mirja{\vc}i{\'c} Martinovi{\'c} and Annette Kragh Larsen and Vladimir Juri{\vs}i{\'c}},

A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activity

It is found that mbIL-2-activated NK-92 cells can survive and proliferate in vitro and in vivo, independent of exogenous IL-2, while mbil- 2-expressing NK- 92 cells do not support bystander cell survival or proliferation.

NK Cell Dysfunction and Checkpoint Immunotherapy

To fully exploit the potential of NK–based checkpoint immunotherapy, more understanding of the regional features of NK cells in the tumor microenvironment is required and will provide valuable information regarding the dynamic nature of NK cell immune response against tumors.

Cytokines Orchestrating the Natural Killer-Myeloid Cell Crosstalk in the Tumor Microenvironment: Implications for Natural Killer Cell-Based Cancer Immunotherapy

Challenges related to these interactions in unleashing the full potential of endogenous and adoptively infused NK cells are discussed and strategies aiming at improving NK cell-based cancer immunotherapies via pathways involved in the NK-myeloid cell crosstalk in the TME are presented.

IL-21 Signaling in the Tumor Microenvironment.

This chapter summarizes IL-21 characteristics and signaling, its role in immune system components, and its use in cancer immunotherapies.

NK Cell Metabolism and Tumor Microenvironment

The potential effect of TME into NK cell metabolism and its influence in NK cell effector functions is discussed and could represent a potential target to focus on to improve the efficacy of NK cell-based therapies against solid tumors.

Immunoregulatory Functions of the IL-12 Family of Cytokines in Antiviral Systems

A simple introduction to the IL-12 family is provided and their functions relevant to their actions to counteract viral infections are focused on.



Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27

IL-27 acts as a pro-inflammatory cytokine that, in concert with other DC-derived cytokines, hierarchically contributes to NK cells activation and effector functions, which likely contributes to foster the adaptive immune response in different physiopathological conditions.

Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer

This work highlights a recent development in NK cell biology, the identification of innate NK cell memory, and focuses on cytokine-induced memory-like (CIML) NK cells that result from a brief, combined activation with IL-12, IL-15, and IL-18.

Cytokine regulation of natural killer cell effector functions

It is believed that a full understanding of how NK cells become activated and develop their effector functions in response to cytokines and other stimuli may lead to the development of novel immunotherapeutic strategies for the treatment of different types of cancer, viral infections, and chronic autoimmune diseases.

Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4.

A molecular framework is provided to understand the interaction between IL-2 and IL-12 in NK cells, and strategies for improving the effectiveness of these cytokines in the immunotherapy of cancer are suggested.

Developmental and Functional Control of Natural Killer Cells by Cytokines

The characteristics of each cytokine and the existing protocols to expand NK cells using different combinations of cytokines and feeder cells are described to aid the generation of better efficacy for adoptive NK cell treatment.

Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.

It is shown that IL-18 converts a subset of Kit(-) (CD11b(-)) into Kit(+) natural killer (NK) cells, which accumulate in all lymphoid organs of tumor bearers and mediate immunoablative functions.

Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation

The results suggest that IL-23 may trigger NK cell-mediated “helper” effects on adaptive immunity, shaping T cell responses during different pathological situations through the regulation of DC maturation.

NK cells and interferons.