The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma

@article{Abraham2011TheRO,
  title={The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma},
  author={Ronnie M. Abraham and Q. Zhang and N. Odum and M. Wasik},
  journal={Cancer Biology & Therapy},
  year={2011},
  volume={12},
  pages={1019 - 1022}
}
  • Ronnie M. Abraham, Q. Zhang, +1 author M. Wasik
  • Published 2011
  • Biology, Medicine
  • Cancer Biology & Therapy
  • Cutaneous T-cell lymphoma (CTCL) displays immunosuppressive properties and phenotypic plasticity. The malignant T cells in CTCL can possess features of immunomodulating regulatory T cells (Treg) and IL-17-producing helper T cells (Th17) depending on the stimuli they receive from antigen presenting cells and other sources. IL-2-type cytokines activate STAT5 to promote expression of Treg-related FoxP3, while various cytokines can activate STAT3 to induce synthesis of IL-10 and IL-17. When the… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES
    Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.
    • 36
    STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.
    • 124
    • PDF
    Regulatory T cells and tumor immunity
    • 91
    Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome
    • 82
    • PDF