The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma.

@article{Abraham2011TheRO,
  title={The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma.},
  author={Ronnie M. Abraham and Qian Zhang and Niels Odum and Mariusz A Wasik},
  journal={Cancer biology & therapy},
  year={2011},
  volume={12 12},
  pages={1019-22}
}
Cutaneous T-cell lymphoma (CTCL) displays immunosuppressive properties and phenotypic plasticity. The malignant T cells in CTCL can possess features of immunomodulating regulatory T cells (Treg) and IL-17-producing helper T cells (Th17) depending on the stimuli they receive from antigen presenting cells and other sources. IL-2-type cytokines activate STAT5 to promote expression of Treg-related FoxP3, while various cytokines can activate STAT3 to induce synthesis of IL-10 and IL-17. When the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Epigenetic regulation of FoxP3 expression in regulatory T cells by DNA methylation

G Lal, N Zhang, +3 authors EP Bottinger
J Immunol • 2009

Similar Papers

Loading similar papers…