The role of cytochrome P-450 in the regulation of steroid biosynthesis.

  • Phillip Hall
  • Published 1976 in Advances in experimental medicine and biology


A cytochrome P-450 from bovine adrenocortical mitochondria has been purified to near homogeneity. The protein catalyzes side-chain cleavage of cholesterol (cholesterol leads to pregnenolone) but neither 11beta- nor 18-hydroxylation. It consists of 16 subunits of two species (MW 52,000) and contains 8 heme groups. The enzyme has been used to determine the… (More)