The role of cysteine in tellurate reduction and toxicity

@article{Goff2021TheRO,
  title={The role of cysteine in tellurate reduction and toxicity},
  author={Jennifer L. Goff and Maxim I. Boyanov and Kenneth M. Kemner and Nathan W. Yee},
  journal={BioMetals},
  year={2021},
  volume={34},
  pages={937-946}
}
The tellurium oxyanion tellurate is toxic to living organisms even at low concentrations; however, its mechanism of toxicity is poorly understood. Here, we show that exposure of Escherichia coli K-12 to tellurate results in reduction to elemental tellurium (Te[0]) and the formation of intracellular reactive oxygen species (ROS). Toxicity assays performed with E. coli indicated that pre-oxidation of the intracellular thiol pools increases cellular resistance to tellurate—suggesting that… 
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