The role of cyclosporine A and interleukin-2 in obliterative airway disease in a rat tracheal transplant model.

@article{Gu2000TheRO,
  title={The role of cyclosporine A and interleukin-2 in obliterative airway disease in a rat tracheal transplant model.},
  author={Yusu Gu and Motoshi Takao and Masashi Kai and Li Ying Lu and Akira Shimamoto and Koji Onoda and Takatsugu Shimono and Keiji Tanaka and Hideto Shimpo and Takeshi Shiraishi and Isao Yada},
  journal={Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia},
  year={2000},
  volume={6 4},
  pages={224-31}
}
The pathogenesis of obliterative bronchiolitis (OB) following lung and heart-lung transplantation remains unclear. We evaluated the role of CsA and IL-2 on the development of obliterative airway disease (OAD) by administrating exogenous IL-2 in a CsA-treated rat tracheal transplant model. Tracheal grafts were implanted into the peritoneal cavity from Brown Norway (BN) to BN rats or to Lewis (LEW) rats. Allotransplant: No treatment was given in group 1. Short-term CsA (25 mg/kg, i.m. on POD 2… CONTINUE READING
2 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…