The role of cyclooxygenase inhibitors in cancer prevention.

  title={The role of cyclooxygenase inhibitors in cancer prevention.},
  author={W. French Anderson and Asad Umar and Jaye L. Viner and Ernest T. Hawk},
  journal={Current pharmaceutical design},
  volume={8 12},
Carcinogenesis results from the long-term accumulation of genetic and epigenetic aberrations at the molecular level, which are under constant selection pressure for growth advantage. Recognizing that cancer is the result of this long-term, multi-step process provides opportunities for molecularly targeted cancer prevention. Ideally, chemopreventive agents should be low in toxicity, morbidity, and cost. Several individual agents and agent combinations are currently under evaluation in the U.S… CONTINUE READING


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