The role of cyclooxygenase (COX)-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration.

@article{Peanha2010TheRO,
  title={The role of cyclooxygenase (COX)-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration.},
  author={Franck Maciel Peçanha and Giulia Alessandra Wiggers and Ana Mar{\'i}a Briones and Jos{\'e} V P{\'e}rez-Gir{\'o}n and Marta Miguel and Ana Bel{\'e}n Garc{\'i}a-Redondo and Dalton Valentin Vassallo and Mar{\'i}a Jes{\'u}s Alonso and Mercedes Sala{\'i}ces},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2010},
  volume={61 1},
  pages={29-36}
}
We have previously demonstrated that chronic exposure to low-dose of mercury induced endothelial dysfunction and increased vasoconstrictor responses. The aim of this work was to investigate if mercury exposure alters contractile prostanoids production from cyclooxygenase-2 (COX-2) and its contribution to phenylephrine responses. For this, aortic segments from 3-month old Wistar rats daily treated with HgCl(2) (1(st) dose 4.6 microg/kg, subsequent dose 0.07 microg/kg/day, i.m.) or vehicle for 30… CONTINUE READING
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