The role of cotranscriptional histone methylations.

  title={The role of cotranscriptional histone methylations.},
  author={Stephen Buratowski and Taesoo Kim},
  journal={Cold Spring Harbor symposia on quantitative biology},
The carboxy-terminal domain (CTD) of the RNA polymerase II subunit Rpb1 undergoes dynamic phosphorylation, with different phosphorylation sites predominating at different stages of transcription. Our laboratory studies show how various mRNA-processing and chromatin-modifying enzymes interact with the phosphorylated CTD to efficiently produce mRNAs. The H3K36 methyltransferase Set2 interacts with CTD carrying phosphorylations characteristic of downstream elongation complexes, and the resulting… CONTINUE READING