The role of corticotropin-releasing hormone in the pathophysiology of depression: therapeutic implications.

@article{Lloyd2011TheRO,
  title={The role of corticotropin-releasing hormone in the pathophysiology of depression: therapeutic implications.},
  author={Robert Brett Lloyd and Charles B. Nemeroff},
  journal={Current topics in medicinal chemistry},
  year={2011},
  volume={11 6},
  pages={
          609-17
        }
}
Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research focused on delineating the function of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently examined its role in mediating the mammalian stress responses and its hyperactivity in depression. Much… CONTINUE READING
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