The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease.

@article{OKane2006TheRO,
  title={The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease.},
  author={Marina O'Kane and Evelyn Patricia Murphy and Brian Kirby},
  journal={Experimental dermatology},
  year={2006},
  volume={15 3},
  pages={
          143-53
        }
}
Corticotropin-releasing hormone (CRH) coordinates the systemic stress response via hypothalamic-pituitary-adrenal (HPA) axis activation with subsequent modulation of the inflammatory response. Stress is known to affect expression of immune-mediated inflammatory diseases, many of which are associated with HPA axis abnormalities. HPA axis components including CRH and its receptors (CRH-R) exist in the skin and exhibit differential expression according to cell type, physiological fluctuations and… CONTINUE READING

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