The role of corticotropin-releasing factor in pain and analgesia.

  title={The role of corticotropin-releasing factor in pain and analgesia.},
  author={William R. Lariviere and Ronald Melzack},
  volume={84 1},
Corticotropin-releasing factor (CRF) is a peptide that is released from the hypothalamus and in widespread areas of the brain following exposure to stressors. It is considered to be a mediator of many of the effects of stress, and its analgesic properties have been demonstrated in many studies. However, for primarily methodological reasons, the effects of CRF in the central nervous system have been neglected whereas the peripheral effects of CRF have been overemphasized. We present evidence… CONTINUE READING
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