The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency

@article{Verbeeten2018TheRO,
  title={The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency},
  author={Kate C Verbeeten and Alexandra Ahmet},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2018},
  volume={31},
  pages={107 - 115}
}
Abstract Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation. In the assessment of adrenal insufficiency, many clinicians measure a total serum cortisol level, which assumes that CBG is present in normal concentrations and with a normal binding affinity for cortisol. CBG concentration and affinity are affected by a number of common factors including oral contraceptive pills (OCPs), fever and infection, as well as rare mutations in… Expand
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