The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy.

@article{Kozak1998TheRO,
  title={The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy.},
  author={Sylwester Kozak and Clark B. Inderlied and Hugo Y. Hsu and Katherine Bristow Heller and Alfredo Arrigo Sadun},
  journal={Diagnostic microbiology and infectious disease},
  year={1998},
  volume={30 2},
  pages={
          83-7
        }
}
The principal side effect of the antimycobacterial agent ethambutol (EMB) is an optic neuropathy with clinical features very similar to a mitochondrial hereditary optic neuropathy (Leber's). The mechanism of EMB-induced optic neuropathy may be EMB's chelation of copper, thereby precluding normal cytochrome c oxidase activity and mitochondrial metabolism in the optic nerve. Before attempting to use therapeutic copper to replenish endogenous stores in an attempt to preclude EMB-induced optic… CONTINUE READING
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Ethambutol optic neuropathy.

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