The role of conventional pathology and toxicology in evaluating the immunotoxic potential of xenobiotics.

@article{Bloom1987TheRO,
  title={The role of conventional pathology and toxicology in evaluating the immunotoxic potential of xenobiotics.},
  author={J. Corey – Bloom and P A Thiem and Daniel G Morgan},
  journal={Toxicologic pathology},
  year={1987},
  volume={15 3},
  pages={283-93}
}
Investigating the immunotoxic potential of candidate drugs as part of a preclinical safety evaluation poses several problems. These include the need for practical, validated tests, the difficulty in establishing the toxicologic significance of positive findings, and a poor understanding of the predictive value such findings hold for drug effects in man. A… CONTINUE READING