The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.

@article{Schmidt2012TheRO,
  title={The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.},
  author={Friederike Schmidt and Denise Dietrich and Roy Eylenstein and Yvonne Groemping and Thilo Stehle and Gabriele Dodt},
  journal={Traffic},
  year={2012},
  volume={13 9},
  pages={1244-60}
}
The human peroxins PEX3 and PEX19 are essential for peroxisome biogenesis. They mediate the import of membrane proteins as well as the de novo formation of peroxisomes. PEX19 binds newly synthesized peroxisomal membrane proteins post-translationally and directs them to peroxisomes by engaging PEX3, a protein anchored in the peroxisomal membrane. After protein insertion into the lipid bilayer, PEX19 is released back to the cytosol. Crystallographic analysis provided detailed insights into the… CONTINUE READING
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