The role of connexins in human disease.

  title={The role of connexins in human disease.},
  author={Eugene Hanyoung Chang and Guy Van Camp and Richard J. H. Smith},
  journal={Ear and hearing},
  volume={24 4},
Connexins are the building blocks of gap junctions. In forming a gap junction, six connexins oligomerize to form a hexameric torus called a connexon. The number of gap junctions in a cell ranges from a few to over 105 and imparts to interconnected cells a uniform phenotype. The crucial role that gap junctions play in normal physiology is reflected by the… CONTINUE READING