The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis.

@article{Morita1997TheRO,
  title={The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis.},
  author={Yusuke Morita and Akiyoshi Nomura and Yukio Yuzawa and Kazuhiro Nishikawa and Nigishi Hotta and Fujio Shimizu and Seiichi Matsuo},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1997},
  volume={8 9},
  pages={1363-72}
}
Persistent proteinuria and tubulointerstitial lesions are important signs of progressive renal disease. The purpose of this study was to assess the role of complement in the development of tubulointerstitial lesions in rats with proteinuria due to primary glomerulonephritis. Mesangial proliferative glomerulonephritis was induced in mononephrectomized rats by intravenous injection of monoclonal antibody (mAb) 1-22-3 (Clin Exp Immunol 102: 181-185, 1995). As early as 24 h after the injection… CONTINUE READING