The role of complement in the localization of pneumococci in the splanchnic reticuloendothelial system during experimental bacteremia.


Pneumococci activate the alternative complement (C) pathway in the absence of demonstrable antibody in normal guinea pig serum. They also activate the classical C pathway in the presence of type-specific antibody and perhaps through other mechanisms as well. A quantitative examination was undertaken of the roles of these 2 pathways of C activation in the… (More)


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