The role of complement in Alzheimer's disease pathology.

  title={The role of complement in Alzheimer's disease pathology.},
  author={Mark R. Emmerling and Martin D. Watson and C A Raby and Katrin Spiegel},
  journal={Biochimica et biophysica acta},
  volume={1502 1},
Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer's dementia. This review will examine the origins of complement in the brain and the role of beta-amyloid peptide (Abeta) in complement activation in Alzheimer's disease, an event that might serve as a nidus of chronic inflammation. Pharmacology… CONTINUE READING

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