The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling.

@article{Leclair2007TheRO,
  title={The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling.},
  author={Ren{\'e}e J Leclair and Volkhard Lindner},
  journal={Trends in cardiovascular medicine},
  year={2007},
  volume={17 6},
  pages={
          202-5
        }
}
  • Renée J Leclair, Volkhard Lindner
  • Published in
    Trends in cardiovascular…
    2007
  • Biology, Medicine
  • Collagen triple helix repeat containing protein 1 (Cthrc1) is a gene product with novel biochemical activities, and its ability to reduce collagen deposition by inhibition of Smad2/3 activation could have major clinical applications in the fields of vascular disease, repair, and fibrosis. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including… CONTINUE READING

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