The role of clinical phenotypes in understanding the genetics of obsessive-compulsive disorder.

@article{Eapen2006TheRO,
  title={The role of clinical phenotypes in understanding the genetics of obsessive-compulsive disorder.},
  author={Valsamma Eapen and David L. Pauls and Mary May Robertson},
  journal={Journal of psychosomatic research},
  year={2006},
  volume={61 3},
  pages={359-64}
}
Studies have shown that genetic factors are significant in predisposing individuals to obsessive-compulsive disorder (OCD). Family studies have demonstrated significantly higher rates of OCD in parents and siblings of OCD probands with an age-corrected morbid risk ranging from approximately 10% to 35% in first-degree relatives. Twin studies suggest that this familiality is, in part, due to genetic factors, and results from complex segregation analyses imply the existence of genes that have… CONTINUE READING