The role of chronic infection in children with otitis media with effusion: evidence for intracellular persistence of bacteria.

@article{Coates2008TheRO,
  title={The role of chronic infection in children with otitis media with effusion: evidence for intracellular persistence of bacteria.},
  author={Harvey L C Coates and Ruth B. Thornton and Jennifer Langlands and Pierre Filion and Anthony David Keil and Shyan Vijayasekaran and Peter Richmond},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={2008},
  volume={138 6},
  pages={
          778-81
        }
}
OBJECTIVE Demonstrate mucosal bacterial infection in children with otitis media with effusion (OME). STUDY DESIGN AND SETTING Middle ear mucosal biopsies from 11 children with OME were examined for bacteria utilizing transmission electron microscopy. This was correlated with standard culture and polymerase chain reaction (PCR) of middle ear effusions. RESULTS Gram-positive coccal bacteria were demonstrated in middle ear mucosal epithelial cells of 4 of 11 (36%) children. Morphological… CONTINUE READING
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