The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

@article{Galtrey2007TheRO,
  title={The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system},
  author={Clare M. Galtrey and James W. Fawcett},
  journal={Brain Research Reviews},
  year={2007},
  volume={54},
  pages={1-18}
}
Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate.
TLDR
Recent studies have shown that CSPGs not only act as non-specific physical barriers that prevent rearrangement of synaptic connections but also regulate neural plasticity through specific interaction of CS chains with its binding partners in a manner that depends on the structure of the CS chain.
Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair
TLDR
The role of C SPGs as inhibitors, the role of inflammation in stimulating CSPG expression near site of injury, and therapeutic strategies for overcoming the inhibitory effects of CSPGs and creating an environment conducive to nerve regeneration are discussed.
Characterisation of semaphorin 3A-chondroitin sulphate interaction in the central nervous system
TLDR
The detail characterization of Sema3A-CS interaction may enable the design of new strategies aiming at enhancing plasticity and regeneration for neurodegenerative diseases or spinal cord injury.
Inhibition of Chondroitin Sulfate Proteoglycans by APRIL.
TLDR
In vitro methods to evaluate APRIL's ability to block CSPGs from interacting with their partner proteins and promote neuronal growth are described.
DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain.
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It is suggested that chondroitin sulfate proteoglycans (CSPG) are responsible for unsuccessful axonal regeneration in glial scars, and the most effective combination of these treatments needs to be examined in the future.
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TLDR
This enzyme has now been shown to restore synaptic plasticity in the visual cortex of adult rats by disrupting perineuronal nets, which contain high levels of chondroitin sulphate proteoglycans (CS‐PGs) and are expressed postnatally around groups of certain neurons in the normal CNS.
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