Corpus ID: 10722882

The role of cholesterol oxidation products in the pathogenesis of atherosclerosis.

@article{Morin1989TheRO,
  title={The role of cholesterol oxidation products in the pathogenesis of atherosclerosis.},
  author={R. Morin and S. Peng},
  journal={Annals of clinical and laboratory science},
  year={1989},
  volume={19 4},
  pages={
          225-37
        }
}
  • R. Morin, S. Peng
  • Published 1989
  • Chemistry, Medicine
  • Annals of clinical and laboratory science
Cholesterol undergoes spontaneous autoxidation, leading to the production of potentially atherogenic oxidation derivatives. When 25-hydroxycholesterol (25-OH) or cholestane-3 beta, 5 alpha, 6 beta-triol (triol) was injected intravenously into rabbits, the aortic surfaces showed numerous balloon-like protrusions and crater-like defects indicative of endothelial damage. Alterations in membrane function caused by these cholesterol oxides could be the mechanism for their cytotoxic effect. Carrier… Expand
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Distribution of oxysterols in human serum: Characterization of 25-hydroxycholesterol association with serum albumin
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References

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Influence of Cholesterol Oxidation Derivatives on Membrane Bound Enzymes in Cultured Aortic Smooth Muscle Cells 1
  • S. Peng, J. Hill, R. Morin, C. B. Taylor
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1985
TLDR
It was demonstrated that 5′-nucleotidase activity was also markedly decreased in plasma membrane-enriched fractions when cells were incubated with cholestane-3β,5α,6β-triol, and Na+, K+-ATPase activity in crude membranes showed a significant decrease. Expand
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TLDR
Transmission electron-microscopic studies showed intracytoplasmic vacuoles and diffuse subendothelial edema in the aortae of the two groups receiving the oxidation derivatives of cholesterol. Expand
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The cytotoxicity of oxygenated derivatives of cholesterol on the cultured cells may not only be due to their potent inhibition of cholesterol biosynthesis, but also could be related to theirExpand
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TLDR
The triol was most active in its cytopathic effect on cells in culture, in size of granuloma formation and in producing necrosis, and the epoxide, 25-hydroxycholesterol and air-oxidized cholesterol produced rather less effect on tissues and cultures than the triol, but more than purified cholesterol and the control. Expand
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TLDR
Oxysterols inhibit HMG-CoA reductase activity resulting in a decreased cholesterol concentration in the cell membrane, which leads to endothelial membrane injury and probable premature cell death. Expand
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TLDR
The experiments demonstrate the feasibility of using reconstituted LDL to selectively deliver hydrophobic compounds other than typical cholesteryl esters to cells possessing LDL receptors and alter the growth or morphology of mutant fibroblasts lacking LDL receptors. Expand
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TLDR
It is indicated that when human VLDL or LDL Is prepared under conditions allowing oxidation, such oxidation renders the molecular complexes highly toxic to human skin flbroblasta growing In culture. Expand
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TLDR
The results suggest that dietary exposure to low levels of cholestane-triol, is atherogenic to a greater degree than exposure to pure cholesterol alone. Expand
Thin-layer chromatographic examination of cholesterol autoxidation
Abstract The air oxidation of cholesterol has been studied by means of one- and two-dimensional thin-layer chromatographic methods herein developed; A semi-quantitative photoelectric densitometricExpand
Angiotoxicity of oxygenated sterols and possible precursors.
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenatedExpand
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