The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils.

@article{Painter2008TheRO,
  title={The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils.},
  author={Richard G. Painter and Ryan W Bonvillain and Vincent G. Valentine and Gisele A Lombard and Stephanie G Laplace and William M Nauseef and Guoshun Wang},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={83 6},
  pages={1345-53}
}
Chloride anion is essential for myeloperoxidase (MPO) to produce hypochlorous acid (HOCl) in polymorphonuclear neutrophils (PMNs). To define whether chloride availability to PMNs affects their HOCl production and microbicidal capacity, we examined how extracellular chloride concentration affects killing of Pseudomonas aeruginosa (PsA) by normal neutrophils. PMN-mediated bacterial killing was strongly dependent on extracellular chloride concentration. Neutrophils in a chloride-deficient medium… CONTINUE READING
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com