The role of chemokines in neutrophil biology.

  title={The role of chemokines in neutrophil biology.},
  author={Yoshiro Kobayashi},
  journal={Frontiers in bioscience : a journal and virtual library},
  • Yoshiro Kobayashi
  • Published 2008 in
    Frontiers in bioscience : a journal and virtual…
Neutrophils are the first to be recruited to a site of infection or a diseased site. Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment. Neutrophils have been considered as effector cells that kill bacteria or destroy affected tissues mainly through the production of reactive oxygen species. Recent studies, however, revealed that neutrophils are involved in the production of chemokines in response… CONTINUE READING