The role of chaperones in polyglutamine disease.


The "triplet repeat" neurodegenerative diseases are linked by a common mode of pathogenicity, wherein a polyglutamine expansion within the relevant disease-causing protein induces toxicity. Although details underlying pathogenesis are largely unknown, protein chaperones appear to be effective suppressors of toxicity in various experimental models… (More)


Cite this paper

@article{Opal2002TheRO, title={The role of chaperones in polyglutamine disease.}, author={Puneet Opal and Huda Y. Zoghbi}, journal={Trends in molecular medicine}, year={2002}, volume={8 5}, pages={232-6} }