The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs

  title={The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs},
  author={Tsuneyuki Yamamoto and Showa Ueki},
  journal={Pharmacology Biochemistry and Behavior},
Central Serotonergic Mechanisms on Head Twitch Response Induced by Benzodiazepine Receptor Agonists
The results suggest that the HTR induced by BZ-RAs may be the result of an activation of postsynaptic 5-HT2 receptors, probably due to direct action.
Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice
It is indicated that dietary thiamine deficiency causes a super-sensitivity of 5-HT2A receptors by reducing presynaptic 5- HT synthesis derived from degenerating neurons projecting from the raphe nucleus.
Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonists
It is concluded that inhibition of mescaline‐induced head‐twitches in the rat is a valid measure of serotonin S2 antagonist activity, also for those compounds whose primary activity occurs at dopamine, norepinephrine, histamine, or acetylcholine receptors.
Nootropic candidates inhibit head-twitches induced by mescaline in mice.
The results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.
Effect of zotepine on head-twitch induced by L-5-hydroxytryptophan, mescaline and 2,5-dimethoxy-4-methylamphetamine in mice and rats.
Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three drugs, indicating that zotEPine has a potent anti-hallucinogenic effect.


5-Methoxytryptamine-induced head twitches in rats.
The results suggest the 5-MT-induced head twitches are due to the activation of the central 5-HT mechanisms probably as a result of direct stimulation of 5- HT receptors by 5- MT, and the dissociation of doses effective in this test from those inhibiting the pinna reflex may be of value in the prediction of central 5 -HT receptor blocking properties.
Effects of reserpine, para‐chlorophenylalanine, 5,6‐dihydroxytryptamine and fludiazepam on the head twitches induced by 5‐hydroxytryptamine or 5‐methoxytryptamine in mice
The stimulants of the methylphenidate group cause less tolerance than those of the amphetamine group (Biel, 19701), which is understood by the proposed difference in the mode of action between these goups of stimulants.
2,5-Dimethoxy-4-methylamphetamine (DOM), a neuropharmacological examination.
2,5-dimethoxy-4-methylamphetamine induces hypersynchrony and behavioral changes similar to those induced by perception distorting psychotomimetic drugs such as LSD and mescaline, but does not induce the electroencephalogram desynchronization or stereotyped behavior previously described for amphetamine.
Action of psychotogenic drugs on single midbrain raphe neurons.
The results indicate that the indole and phenethylamine psychotogens, which have similar effects on behavior, also have an overlapping although not identical effect on single units in the raphe nuclei.
A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine.
Evidence is presented that the head-twitches are due to a central action of 5-hydroxytryptamine formed by decarboxylation of 5.hydroxyTryptophan, and the method may be valuable in the preliminary examination of compounds likely to have a centralaction.
p-Chlorophenylalanine: a specific depletor of brain serotonin.
  • B. Koe, A. Weissman
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1966
The results suggest that p -chlorophenylalanine may effect 5HT depletion by inhibiting the biosynthesis of this monoamine, possibly by blocking tryptophan hydroxylation.
Behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rats and mice.
Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide
It was found that LSD reduced the turnover rate of brain and spinal cord 5‐HT, studied after inhibition of the tryptophan hydroxylase by α‐propyldopacet‐amide, which indicates that LSD stimulates central 5-HT receptors.