The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs

@article{Yamamoto1981TheRO,
  title={The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs},
  author={Tsuneyuki Yamamoto and Showa Ueki},
  journal={Pharmacology Biochemistry and Behavior},
  year={1981},
  volume={14},
  pages={89-95}
}
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48 Citations
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48 Citations

Central Serotonergic Mechanisms on Head Twitch Response Induced by Benzodiazepine Receptor Agonists
TLDR
The results suggest that the HTR induced by BZ-RAs may be the result of an activation of postsynaptic 5-HT2 receptors, probably due to direct action.
Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice
TLDR
It is indicated that dietary thiamine deficiency causes a super-sensitivity of 5-HT2A receptors by reducing presynaptic 5- HT synthesis derived from degenerating neurons projecting from the raphe nucleus.
Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives.
Phencyclidine-induced head-twitch response in rats treated chronically with methysergide.
Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonists
TLDR
It is concluded that inhibition of mescaline‐induced head‐twitches in the rat is a valid measure of serotonin S2 antagonist activity, also for those compounds whose primary activity occurs at dopamine, norepinephrine, histamine, or acetylcholine receptors.
Phencyclidine-induced head-weaving and head-twitch through interaction with 5-HT1 and 5-HT2 receptors in reserpinized rats
Nootropic candidates inhibit head-twitches induced by mescaline in mice.
TLDR
The results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.
Parachloroamphetamine selectively alters regional cerebral metabolic responses to the serotonergic agonist metachlorophenylpiperazine in rats
Effect of zotepine on head-twitch induced by L-5-hydroxytryptophan, mescaline and 2,5-dimethoxy-4-methylamphetamine in mice and rats.
TLDR
Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three drugs, indicating that zotEPine has a potent anti-hallucinogenic effect.
Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats.
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