The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs

@article{Yamamoto1981TheRO,
  title={The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs},
  author={T. Yamamoto and S. Ueki},
  journal={Pharmacology Biochemistry and Behavior},
  year={1981},
  volume={14},
  pages={89-95}
}
  • T. Yamamoto, S. Ueki
  • Published 1981
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • Head-twitch induced by lysergic acid diethylamide, mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) was significantly increased by medial raphe (m-R) lesions, but dorsal raphe (d-R) lesions did not produce any changes. Hallucinogen-induced head twitch was inhibited by methysergide and tended to be increased by PCPA. These results suggest that 5-HT receptors innervated with the ascending 5-HT pathway originating in the m-R play a vital role in the manifestation of hallucinogen-induced head… CONTINUE READING
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