The role of central mu opioid receptors in opioid-induced itch in primates.

@article{Ko2004TheRO,
  title={The role of central mu opioid receptors in opioid-induced itch in primates.},
  author={M C Ko and Michael S Song and T. J. Edwards and Heeseung Lee and Norah N Naughton},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={310 1},
  pages={169-76}
}
Pruritus (itch sensation) is a significant clinical problem. The aim of this study was to elucidate the roles of opioid receptor types and the site of action in opioid-induced itch in monkeys. Observers who were blinded to the conditions counted scratching after administration of various drugs. Intravenous (i.v.) administration of mu opioid receptor (MOR) agonists (fentanyl, alfentanil, remifentanil, and morphine) evoked scratching in a dose- and time-dependent manner. However, the kappa opioid… CONTINUE READING

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