The role of central histamine H1- and H2-receptors in hypothermia induced by histamine in the rat

@article{Bugajski1981TheRO,
  title={The role of central histamine H1- and H2-receptors in hypothermia induced by histamine in the rat},
  author={Jan Bugajski and Elżbieta Zacny},
  journal={Agents and Actions},
  year={1981},
  volume={11},
  pages={442-447}
}
Histamine administered intraventricularly or into the anterior hypothalamic preoptic region induced dosedependent hypothermia in rats with chronic i.c.v. cannula. This hypothermia was almost totally abolished by both the histamine H1-and H2-receptor antagonists, mepyramine or chloropyramine and metiamide or cimetidine, respectively, given i.c.v. prior to histamine. In behavioural thermoregulation studies histamine considerably diminished the mean duration of dwelling of the rat under the heat… CONTINUE READING