The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging.

@article{Davis2007TheRO,
  title={The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging.},
  author={Terence Davis and Fiona S. Wyllie and Michal J. Rokicki and Mark C. Bagley and David Kipling},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1100},
  pages={455-69}
}
Werner syndrome (WS) is a premature aging disorder used as a model of normal human aging. WS individuals have several characteristics of normal aging, such as cataracts, hair graying, and skin aging, but manifest these at an early age. Additionally, WS individuals have high levels of inflammatory diseases, such as atherosclerosis and type 2 diabetes. The in vivo aging in WS is associated with accelerated aging of fibroblasts in culture. The cause of the accelerated senescence is not understood… CONTINUE READING

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