The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse.

@article{Gohlke2004TheRO,
  title={The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse.},
  author={Julia M. Gohlke and William C. Griffith and Elaine M. Faustman},
  journal={Brain research. Developmental brain research},
  year={2004},
  volume={151 1-2},
  pages={43-54}
}
We are quantitatively evaluating the acquisition of neocortical neurons through key stages of development including neurogenesis, migration, and synaptogenesis. Here we expand upon a previous computational model describing neocortical neurogenesis in the rat and mouse [Dev. Neurosci. 24 (2002) 467], to include the period of synaptogenesis (P0-P14) when programmed cell death (PCD) is known to play a major role in shaping the neocortex. We also quantitatively evaluate differing hypotheses on the… CONTINUE READING

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