The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.

@article{Yasuda2005TheRO,
  title={The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.},
  author={Yoshiyuki Yasuda and Jadwiga Kaleta and Dieter Br{\"o}mme},
  journal={Advanced drug delivery reviews},
  year={2005},
  volume={57 7},
  pages={
          973-93
        }
}
Human cysteine proteases of the papain family have been recognized as potential drug targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K, which display selective expression in cells of the immune system and cells capable to efficiently degrade extracellular matrix proteins, in particular collagens. The predominant expression of cathepsin K in osteoclasts has rendered the enzyme into a major target for the development of novel anti-resorptive drugs in… CONTINUE READING

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