The role of cathepsin E in terminal differentiation of keratinocytes

@inproceedings{Kawakubo2011TheRO,
  title={The role of cathepsin E in terminal differentiation of keratinocytes},
  author={Tomoyo Kawakubo and Atsushi Yasukochi and Kuniaki Okamoto and Yoshiko Okamoto and Seiji Nakamura and Kenji Yamamoto},
  booktitle={Biological chemistry},
  year={2011}
}
Abstract Cathepsin E (CatE) is predominantly expressed in the rapidly regenerating gastric mucosal cells and epidermal keratinocytes, in addition to the immune system cells. However, the role of CatE in these cells remains unclear. Here we report a crucial role of CatE in keratinocyte terminal differentiation. CatE deficiency in mice induces abnormal keratinocyte differentiation in the epidermis and hair follicle, characterized by the significant expansion of corium and the reduction of… 
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