The role of cartilage oligomeric matrix protein (COMP) in skeletal disease.

  title={The role of cartilage oligomeric matrix protein (COMP) in skeletal disease.},
  author={Karen LaShea Posey and Jacqueline Tauber Hecht},
  journal={Current drug targets},
  volume={9 10},
Cartilage oligomeric matrix protein is a non-collagenous extracellular matrix protein expressed primarily in cartilage, ligament, and tendon. Cartilage oligomeric matrix protein has been studied extensively because mutations in the gene cause two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia. Pseudoachondroplasia is a disproportionate dwarfing condition associated with joint abnormalities, while multiple epiphyseal dysplasia is less severe. Both of these skeletal… CONTINUE READING
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