The role of cardiac glycosides in influencing breast cancer cell proliferation

Abstract

Introduction Cardiac Glycosides (CGs) are commonly used to treat congestive heart failure. CGs inhibit the Sodium Potassium ATPase (Na+/K+ ATPase) pump. Interestingly, CGs have been suggested to inhibit proliferation and migration of breast cancer cells. A pool of non-pumping Na+/K+ ATPase reportedly localizes in specific membrane organelles, caveolae, by… (More)

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