The role of carbonic anhydrase IX overexpression in kidney cancer.

  title={The role of carbonic anhydrase IX overexpression in kidney cancer.},
  author={Thambi Dorai and Ihor S. Sawczuk and Jarom{\'i}r Pastorek and Peter H. Wiernik and Janice P Dutcher},
  journal={European journal of cancer},
  volume={41 18},
Carbonic anhydrase IX (CA IX) is a membrane isoenzyme, the overexpression of which is associated with clear cell carcinoma of the kidney. Its overexpression is restricted mainly to cancer, as it is absent in corresponding normal tissues making it a potential cancer biomarker. Several recent studies have shown that CA IX, apart from its classical enzyme activity of reversibly hydrating carbon dioxide extracellularly to facilitate the net extrusion of protons from inside to outside the cell, it… CONTINUE READING
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