The role of cancer stem cells in glioblastoma.

  title={The role of cancer stem cells in glioblastoma.},
  author={Swetha J. Sundar and Jason K Hsieh and Sunil Manjila and Justin D Lathia and Andrew Sloan},
  journal={Neurosurgical focus},
  volume={37 6},
Recurrence in glioblastoma is nearly universal, and its prognosis remains dismal despite significant advances in treatment over the past decade. Glioblastoma demonstrates considerable intratumoral phenotypic and molecular heterogeneity and contains a population of cancer stem cells that contributes to tumor propagation, maintenance, and treatment resistance. Cancer stem cells are functionally defined by their ability to self-renew and to differentiate, and they constitute the diverse hierarchy… CONTINUE READING