The role of calpain in diabetes-associated platelet hyperactivation.

  title={The role of calpain in diabetes-associated platelet hyperactivation.},
  author={Voahanginirina Randriamboavonjy and Ingrid Fleming},
  journal={Advances in pharmacology},
Diabetes mellitus is a major risk factor for vascular diseases and is associated with accelerated atherosclerosis and a high rate of arterial thrombotic complications. A number of studies support the concept that platelets contribute to the pathogenesis and progression of the vascular complications of diabetes. µ-Calpain, a non-lysosomal, Ca(2+)-dependent cysteine protease, is expressed in platelets and is involved in physiological platelet activation. However, the inappropriate activation of… CONTINUE READING