The role of calcium ions in the mechanism of acth stimulation of cortisol synthesis

@article{Davies1985TheRO,
  title={The role of calcium ions in the mechanism of acth stimulation of cortisol synthesis},
  author={Eleanor Davies and Christopher J. Kenyon and Robert Fraser},
  journal={Steroids},
  year={1985},
  volume={45},
  pages={551-560}
}
Removal of free calcium ions from the incubation medium of isolated bovine adrenocortical cells with EGTA reduced basal cortisol synthesis and blocked the effects of ACTH; additional calcium restored normal steroid synthesis. Calcium channel blockers, verapamil and nitrendipine and the calmodulin antagonist, trifluoperazine inhibited ACTH-stimulated cortisol synthesis in a dose-dependent manner (IC50s of 6.2, 10 and 5.2 microM, respectively). Steroidogenic effects of dibutyryl cyclic AMP were… Expand
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