The role of calcium in mammalian oocyte maturation and egg activation.

@article{Homa1993TheRO,
  title={The role of calcium in mammalian oocyte maturation and egg activation.},
  author={Sheryl T Homa and John R. Carroll and Karl Swann},
  journal={Human reproduction},
  year={1993},
  volume={8 8},
  pages={
          1274-81
        }
}
The maturation of the immature oocyte and the fertilization of a mature egg are two absolute prerequisites for mammalian embryo development. There is increasing evidence in mammals that both oocyte maturation and egg activation at fertilization are controlled by changes in intracellular free Ca2+ levels. The role of Ca2+ changes at fertilization is clear in that they are both required and sufficient for egg activation. However, it is not established how the sperm causes Ca2+ changes in eggs at… CONTINUE READING
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