The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons.

@article{Cholewinski1993TheRO,
  title={The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons.},
  author={Andrzej Cholewinski and Gillian M. Burgess and Stuart Bevan},
  journal={Neuroscience},
  year={1993},
  volume={55 4},
  pages={1015-23}
}
The effects of capsaicin cytosolic Ca2+ concentration ([Ca2+]i) were measured in individual dorsal root ganglion neurons of the rat in culture. Capsaicin produced a rapid concentration-dependent (EC50 value of 72 nM) increase in [Ca2+]i which was entirely dependent on Ca2+ entry. Exposure of the neurons to a high concentration of capsaicin resulted in desensitization, but only in the presence of external Ca2+. Raising [Ca2+]i with a depolarizing concentration of potassium or the Ca2+ ionophore… CONTINUE READING
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