The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide.

@article{Lordan2009TheRO,
  title={The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide.},
  author={Sin{\'e}ad Lordan and Nora M O'brien and John J. Mackrill},
  journal={Journal of biochemical and molecular toxicology},
  year={2009},
  volume={23 5},
  pages={324-32}
}
Oxysterols, such as 7beta-hydroxy-cholesterol (7beta-OH) and cholesterol-5beta,6beta-epoxide (beta-epoxide), may have a central role in promoting atherogenesis. This is thought to be predominantly due to their ability to induce apoptosis in cells of the vascular wall and in monocytes/macrophages. Although there has been extensive research regarding the mechanisms through which oxysterols induce apoptosis, much remains to be clarified. Given that experimental evidence has long associated… CONTINUE READING
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