The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.

@article{Taylor2011TheRO,
  title={The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.},
  author={Adam M Taylor and Alan Boyde and Peter J. M. Wilson and Jonathan C. Jarvis and John S. Davidson and Jennifer A. Hunt and Lakshminarayan R. Ranganath and Jacqueline A. Gallagher},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 12},
  pages={
          3887-96
        }
}
OBJECTIVE Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid. Homogentisic acid is deposited as a polymer, termed ochronotic pigment, in collagenous tissues, especially cartilages of weight-bearing joints, leading to a severe osteoarthropathy. We undertook this study to investigate the initiation and progression of ochronosis from the earliest detection of pigment through complete joint failure. METHODS Nine joint… CONTINUE READING
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