The role of cAMP-mediated intracellular signaling in regulating Na+ uptake in zebrafish larvae.

@article{Kumai2014TheRO,
  title={The role of cAMP-mediated intracellular signaling in regulating Na+ uptake in zebrafish larvae.},
  author={Yusuke Kumai and Raymond W. M. Kwong and Steve F. Perry},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2014},
  volume={306 1},
  pages={R51-60}
}
In the current study, the role of cAMP in stimulating Na(+) uptake in larval zebrafish was investigated. Treating larvae at 4 days postfertilization (dpf) with 10 μM forskolin or 1 μM 8-bromo cAMP significantly increased Na(+) uptake by three-fold and twofold, respectively. The cAMP-dependent stimulation of Na(+) uptake was probably unrelated to protein trafficking via microtubules because pretreatment with 200 μM colchicine or 30 μM nocodazole did not attenuate the magnitude of the response… CONTINUE READING
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