The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer.

@article{Hsiang1995TheRO,
  title={The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer.},
  author={Y H Hsiang and Jacki P. Goldman and David H Raulet},
  journal={Journal of immunology},
  year={1995},
  volume={154 10},
  pages={5195-204}
}
An enhancer has been localized 3 kb downstream of the C gamma 1 gene segment of the murine TCR-gamma locus. One element, the gamma 3 site, has been shown to be critical for its functional activity. Here we have determined that Myb-related transcription factors bind to the gamma 3 site and appear to be critical for the full activity of the TCR-gamma enhancer. c-myb products can transactivate the gamma 3 site in cell lines that do not ordinarily support enhancer activity of the gamma 3 site… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…