The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior

@article{Stengel2015TheRO,
  title={The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior},
  author={Andreas Stengel and Hiroshi Karasawa and Yvette Tach{\'e}},
  journal={Hormones and Behavior},
  year={2015},
  volume={73},
  pages={15-22}
}
Somatostatin was discovered four decades ago as hypothalamic factor inhibiting growth hormone release. Subsequently, somatostatin was found to be widely distributed throughout the brain and to exert pleiotropic actions via interaction with five somatostatin receptors (sst1-5) that are also widely expressed throughout the brain. Interestingly, in contrast to the predominantly inhibitory actions of peripheral somatostatin, the activation of brain sst2 signaling by intracerebroventricular… CONTINUE READING
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