The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior
@inproceedings{Sher2011TheRO, title={The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior}, author={Leo Sher}, booktitle={International journal of adolescent medicine and health}, year={2011} }
Abstract Adolescent suicide research has mostly focused on demographic risk factors. Such studies focus on who is at risk, but do not explain why certain adolescents are at risk for suicide. Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior has…
14 Citations
The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior.
- Psychology, BiologyPsychiatria Danubina
- 2013
The findings demonstrate that aberrant regulation of BDNF synthesis is associated with suicidal behaviour and could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma.
Exploring the association between depression, suicidality and serum neurotrophin levels in adolescents
- Psychology, MedicineInternational journal of psychiatry in clinical practice
- 2020
The study results suggest that elevated serum BDNF levels may be related to MDD in adolescents, however, the findings did not support a role for neurotrophins in suicidality.
Genetics of Adolescent Suicide: A Literature review
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Adolescent suicidal behavior is a global public health issue; however, genetic studies are sparse and diverse. A review of the current knowledge on the genetics of adolescent suicide based on an…
Serum brain-derived neurotrophic factor levels in subjects with major depressive disorder with previous suicide attempt: A population-based study
- Psychology, BiologyPsychiatry Research
- 2018
CpG methylation of brain-derived the neurotrophic factor gene promoter as a potent diagnostic and prognostic biomarker for post-traumatic stress disorder.
- BiologyInternational journal of clinical and experimental pathology
- 2018
The data support the notion that stressful life events may directly cause CpG methylation in the BDNF promoter of PTSD patients, and provide a new way for the diagnosis and treatment of PTSD.
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
- Psychology, BiologyCytogenetic and Genome Research
- 2015
The methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
Adolescent physical and psychological health: Ethico-legal considerations
- Psychology, Medicine
- 2014
Impact of exercise training on neuroplasticity-related growth factors in adolescents.
- Medicine, BiologyJournal of musculoskeletal & neuronal interactions
- 2013
It was found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones, however, no effect of training was found in the activation of CREB in PBMCs.
Suicidal Ideation, Suicide Attempts and Completed Suicide in Adolescents: Neurobiological Aspects
- Psychology
- 2016
Suicidal behavior is a complex and multidetermined phenomenon that affects countries around the world and all age groups. Adolescence is a critical period in human growth, ranging from 10 to 19 years
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