The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior

  title={The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior},
  author={Leo Sher},
  booktitle={International journal of adolescent medicine and health},
  • L. Sher
  • Published in
    International journal of…
    1 September 2011
  • Psychology, Biology
Abstract Adolescent suicide research has mostly focused on demographic risk factors. Such studies focus on who is at risk, but do not explain why certain adolescents are at risk for suicide. Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior has… 
The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior.
The findings demonstrate that aberrant regulation of BDNF synthesis is associated with suicidal behaviour and could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma.
Exploring the association between depression, suicidality and serum neurotrophin levels in adolescents
The study results suggest that elevated serum BDNF levels may be related to MDD in adolescents, however, the findings did not support a role for neurotrophins in suicidality.
Genetics of Adolescent Suicide: A Literature review
Adolescent suicidal behavior is a global public health issue; however, genetic studies are sparse and diverse. A review of the current knowledge on the genetics of adolescent suicide based on an
CpG methylation of brain-derived the neurotrophic factor gene promoter as a potent diagnostic and prognostic biomarker for post-traumatic stress disorder.
The data support the notion that stressful life events may directly cause CpG methylation in the BDNF promoter of PTSD patients, and provide a new way for the diagnosis and treatment of PTSD.
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
The methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
Impact of exercise training on neuroplasticity-related growth factors in adolescents.
It was found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones, however, no effect of training was found in the activation of CREB in PBMCs.
Suicidal Ideation, Suicide Attempts and Completed Suicide in Adolescents: Neurobiological Aspects
Suicidal behavior is a complex and multidetermined phenomenon that affects countries around the world and all age groups. Adolescence is a critical period in human growth, ranging from 10 to 19 years
Addiction science: Uncovering neurobiological complexity


Brain-derived neurotrophic factor and suicide pathogenesis
Overall, it appears that abnormalities in BDNF signaling may serve as an important biological risk factor in the etiology and pathogenesis of suicide.
Low plasma BDNF is associated with suicidal behavior in major depression
Brain-derived neurotrophic factor: role in depression and suicide
Critical evidence demonstrating the involvement of BDNF in depression and suicide is reviewed, suggesting the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior.
Adolescent suicide
Suicidal behavior remains an important clinical problem and a major cause of death in youth and there are key issues that need to be solved for better prediction of suicidality, prevention and treatment of youth suicide.
Risk of suicide in mood disorders
The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide.
Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions
  • K. Hashimoto
  • Psychology, Biology
    Psychiatry and clinical neurosciences
  • 2010
An historical overview of the role played by BDNF in the pathophysiology of mood disorders and in the mechanism of action of therapeutic agents is provided and particular focus will be given to the potential use of BDNF as a biomarker for mood disorders.
Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs.
Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder