The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior

  title={The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior},
  author={L. Sher},
  booktitle={International journal of adolescent medicine and health},
  • L. Sher
  • Published in
    International journal of…
  • Medicine
Abstract Adolescent suicide research has mostly focused on demographic risk factors. Such studies focus on who is at risk, but do not explain why certain adolescents are at risk for suicide. Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior has… Expand
The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior.
The findings demonstrate that aberrant regulation of BDNF synthesis is associated with suicidal behaviour and could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma. Expand
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CpG methylation of brain-derived the neurotrophic factor gene promoter as a potent diagnostic and prognostic biomarker for post-traumatic stress disorder.
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Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
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Brain-derived neurotrophic factor and suicide pathogenesis
Overall, it appears that abnormalities in BDNF signaling may serve as an important biological risk factor in the etiology and pathogenesis of suicide. Expand
Low plasma BDNF is associated with suicidal behavior in major depression
It is suggested that reduction of plasma BDNF level is related to suicidal behavior in major depression and thatBDNF level may be a biological marker of suicidal depression. Expand
Brain-derived neurotrophic factor: role in depression and suicide
Critical evidence demonstrating the involvement of BDNF in depression and suicide is reviewed, suggesting the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. Expand
Role of neurotrophic factors in behavioral processes: implications for the treatment of psychiatric and neurodegenerative disorders.
  • M. Pardon
  • Medicine, Biology
  • Vitamins and hormones
  • 2010
Brain-derived neurotrophic factor has recently emerged as a key player in the development of drug addiction and is well known to be involved in adaptation to stress and stress-related disorders, while NGF in the other hand is thought to be involvement in aggression and alcohol dependence. Expand
Adolescent suicide
Suicidal behavior remains an important clinical problem and a major cause of death in youth and there are key issues that need to be solved for better prediction of suicidality, prevention and treatment of youth suicide. Expand
Risk of suicide in mood disorders
Abstract Suicide is commonly associated with mood disorders. Risk factors for suicide in mood disorders can be organized according to whether their effect is on the threshold or diathesis forExpand
The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide.
A major role of BDNF in increased vulnerability to suicide is confirmed and the combined Met/Met and Met/Val genotypes of the BDNF Val66Met variant could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma. Expand
Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions
  • K. Hashimoto
  • Psychology, Medicine
  • Psychiatry and clinical neurosciences
  • 2010
An historical overview of the role played by BDNF in the pathophysiology of mood disorders and in the mechanism of action of therapeutic agents is provided and particular focus will be given to the potential use of BDNF as a biomarker for mood disorders. Expand
Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs.
A role of BDNF and NT-3 neurotrophin, in the pathophysiology of suicidal behavior is supported, which may implicate the hippocampus and the PFC but not the entorhinal cortex, and both neurotrophins are mediators of psychotropic drugs. Expand
Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder
The results, while showing significantly lower BDNF levels in PTSD patients, as compared with those of healthy subjects, would suggest that this NT may be involved in the pathophysiology of PTSD. Expand