The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior

@inproceedings{Sher2011TheRO,
  title={The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior},
  author={Leo Sher},
  booktitle={International journal of adolescent medicine and health},
  year={2011}
}
  • L. Sher
  • Published in
    International journal of…
     1 September 2011
  • Psychology, Biology
Abstract Adolescent suicide research has mostly focused on demographic risk factors. Such studies focus on who is at risk, but do not explain why certain adolescents are at risk for suicide. Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior has… 
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14 Citations

The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior.
TLDR
The findings demonstrate that aberrant regulation of BDNF synthesis is associated with suicidal behaviour and could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma.
Exploring the association between depression, suicidality and serum neurotrophin levels in adolescents
TLDR
The study results suggest that elevated serum BDNF levels may be related to MDD in adolescents, however, the findings did not support a role for neurotrophins in suicidality.
Genetics of Adolescent Suicide: A Literature review
Adolescent suicidal behavior is a global public health issue; however, genetic studies are sparse and diverse. A review of the current knowledge on the genetics of adolescent suicide based on an…
Serum brain-derived neurotrophic factor levels in subjects with major depressive disorder with previous suicide attempt: A population-based study
CpG methylation of brain-derived the neurotrophic factor gene promoter as a potent diagnostic and prognostic biomarker for post-traumatic stress disorder.
TLDR
The data support the notion that stressful life events may directly cause CpG methylation in the BDNF promoter of PTSD patients, and provide a new way for the diagnosis and treatment of PTSD.
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
TLDR
The methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
Adolescent physical and psychological health: Ethico-legal considerations
Impact of exercise training on neuroplasticity-related growth factors in adolescents.
TLDR
It was found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones, however, no effect of training was found in the activation of CREB in PBMCs.
Suicidal Ideation, Suicide Attempts and Completed Suicide in Adolescents: Neurobiological Aspects
Suicidal behavior is a complex and multidetermined phenomenon that affects countries around the world and all age groups. Adolescence is a critical period in human growth, ranging from 10 to 19 years
Addiction science: Uncovering neurobiological complexity
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