The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain

@article{Zai2012TheRO,
  title={The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain},
  author={Gwyneth C M Zai and Clement C H Zai and Nabilah I. Chowdhury and Arun Kumar Tiwari and James L Kennedy},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2012},
  volume={39},
  pages={96-101}
}
BACKGROUND Brain-derived neurotrophic factor (BDNF) has extensive effects on the nervous system including cell survival, differentiation, neuronal growth and maintenance, as well as cell death. Moreover, it promotes synaptic plasticity and interacts with dopaminergic and serotonergic neurons, suggesting an important role on the alteration of brain function with antipsychotic medications and induced weight gain in schizophrenia patients. The differential effects of BDNF gene variants could lead… CONTINUE READING
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