The role of bone microenvironment, vitamin D and calcium.

@article{Santini2012TheRO,
  title={The role of bone microenvironment, vitamin D and calcium.},
  author={Daniele Santini and Francesco Pantano and L D'Onofrio and Giuseppe Tonini and Francesco Bertoldo},
  journal={Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer},
  year={2012},
  volume={192},
  pages={33-64}
}
Starting first from Paget's "seed and soil" to the latest hypothesis about metastatic process involving the concept of a premetastatic niche, a large amount of data suggested the idea that metastatization is a multistep coordinated process with a high degree of efficiency. A specific subpopulation of cells with tumor-initiating and migratory capacity can selectively migrate toward sites that are able to promote survival, and/or proliferation of metastatic tumor cells through a microenvironment… CONTINUE READING

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